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CRB-601 monoclonal antibody
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
Ensayo de Corbus Pharmaceuticals Holdings, Inc. en Tumor solido.
Más ensayos de: Tumor sólido.
- Fase
- Fase 1/2
- Estado
- Reclutando pacientes
- Participantes
- 156
- Centros
- 26
- Fin del objetivo primario
- nov 2026
Qué significa cada fase y cada estado.
Estudio de intervención, no aleatorizado, abierto. Comenzó en dic 2024.
Qué mide
Occurance of Dose-limiting toxicities (del registro, en inglés) (28 dias)
Qué se prueba
El estudio busca determinar la seguridad, concentraciones en sangre y efecto de tratamiento de CRB-601 combinado con inmunoterapia en pacientes con tumores sólidos avanzados que agotaron otras opciones.
Lo que dice el documentoThe purpose of this study is to determine the safety, blood concentrations and treatment effect of CRB-601 in combination with immunotherapy in patients who have advanced solid tumors (cancer) and have exhausted other therapeutic options.CRB-601 targets a protein called avb8 integrin which is expressed by some cancers and not others.
Traducción automática (claude-sonnet-5). Lo comprobado es la cita: está literal en el documento y sus cifras cuadran con las de la frase. Todavía no la ha leído una persona.
Cómo lo describe el promotor
En el documentoEn inglés, del registroThe purpose of this study is to determine the safety, blood concentrations and treatment effect of CRB-601 in combination with immunotherapy in patients who have advanced solid tumors (cancer) and have exhausted other therapeutic options.CRB-601 targets a protein called avb8 integrin which is expressed by some cancers and not others. This study will focus on tumor types which are know to highly or moderately express this protein. Researchers will evaluate the side effects caused by treatment, levels of CRB-601 in the blood, and the effect on the participant cancer. This will help researchers understand the right dose of CRB-601 to use for treatment and whether it is an effective treatment to combine with standard of care treatments such as immunotherapy. It will also help the researchers understand whether combining CRB-601 with standard-of-care immunotherapy and immune-priming radiotherapy is a safe and effective approach to treat cancer. Participants in the study will receive CRB-601 via an infusion every two weeks either alone or in combination with immunotherapy. There will be assessments to check on the participants general health status (including blood tests) and adverse effects. Participants will also receive regular CT or MRI scans to evaluate the effect of CRB-601 on their cancer. Participants will continue to visit the clinic every two weeks while they are receiving benefit from treatment. If their cancer progresses, participants will be asked to continue to be followed-up by the researchers to understand long-term outcomes, even if they receive other treatments.
Más ensayos de CRBP
| Ensayo | Fase | Estado | Lectura de resultados |
|---|---|---|---|
| CRB-913 · CANYON-1 | Fase 1 | En marcha, sin reclutar | jul 2026 (prevista, ya pasada: sin actualizar en el registro) |
| CRB-701 | Fase 1/2 | Reclutando pacientes | ene 2027 (prevista) |
| CRB-701 · TEMPO-1 | Fase 3 | Aún sin reclutar | dic 2027 (prevista) |
| Lenabasum 20 mg · DETERMINE | Fase 3 | Completado | mar 2021 (real) |
| Lenabasum 20 mg | Fase 2 | Completado | jun 2020 (real) |
| Lenabasum 5 mg · RESOLVE-1 | Fase 3 | Interrumpido | may 2020 (real) |
Todos los de CRBP, en su ficha.
Ficha completa en ClinicalTrials.gov (NCT06603844), actualizada en may 2025.